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At present it is estimated that marijuanas LD-50 is around 1:20,000 or 1:40,000. In layman terms this means that in order to induce death a marijuana smoker would have to consume 20,000 to 40,000 times as much marijuana as is contained in one marijuana cigarette.

As will be apparent, this corresponds to a CBD:9-THC ratio of between to 2:1. Dalton et al (1976, Clin Pharmacol Ther 19: 300-309) observed attenuation of the 9-THC effects when both CBD and 9-THC were inhaled simultaneously, at 10.5 mg and 1.7 mg respectively (CBD:9-THC.

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